A comprehensive, multi-phase investigation published in Advanced Science suggests that the amino acid tryptophan (Trp) may be a key determinant of therapeutic response to conventional synthetic ...

This study addresses an important question in liver biology: how zonal hepatocytes balance survival and proliferation following injury; using spatial transcriptomics, mechanistic perturbations, and ...

Investigators have developed a prognostic model that may identify which patients with MIBC are suitable for bladder-preserving chemoradiation.

(CE) and methionine restriction (MetR) impacts health and leads to weight loss in mice. The authors provided valuable datasets showing that the responses to MR and CE are tissue-specific, while MR and ...

One such protein, Bromodomain and PHD finger-containing protein 1b (BRPF1b), regulates transcription through multiple chromatin reader domains—including a double PHD and zinc finger assembly, a ...

HIRI and liver transplantation animal models, primary cell co-cultures and adeno-associated virus-mediated gene knockdown were used to prove cellular ... site 2 (MEIS2), leading to increased ...

Alida Biosciences’ EpiPlex platform uses robust assay controls and specialized bioinformatics to detect RNA modification, genomic coordinates, and relative quantity.

Elderberry juice intake triggers metabolic gene expression changes, enhancing glucose control and fat oxidation in overweight ...

Parkinson's disease causes both movement and cognitive deficits, and for a long time both were thought to be caused by the accumulation of a protein called alpha-synuclein in the brain. But a new ...

Biogen has discontinued all gene therapy programs using adeno-associated virus (AAV) capsids, instead shifting resources to modalities that have the highest likelihood of achieving better treatment ...

Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. This work presents FitFoldData, a novel web-based tool for the analysis and ...