As the world struggles with the ongoing COVID-19 pandemic, unprecedented obstacles have continuously been traversed as new SARS-CoV-2 variants continually emerge. Infectious disease outbreaks are ...

Liquid-liquid phase separation (LLPS) has emerged as a major organizing principle in cells. Recent work showed that multiple components of integrin-mediated focal adhesions, including p130Cas can form ...

It follows a previous report showing that the Werner syndrome protein WRN and its interacting protein WRNIP1 are indispensable for translesion DNA synthesis (TLS) by Y-family DNA polymerases (Pols).

The well-studied NF-κB signaling system is a key mediator of the inflammatory response. Large-scale sequencing studies in ...

BACKGROUND: Penetrance and risk of ventricular arrhythmias (VAs) in arrhythmogenic right ventricular cardiomyopathy (ARVC) are increasingly recognized as being genotype specific. Therefore, ...

The ongoing open-label APeX-P study is evaluating the pharmacokinetic, safety, and effectiveness of berotralstat in children aged 2 to 11 years with HAE. Patients were enrolled into four weight-based ...

The matrix and network structure of gluten protein was destroyed (Zhang et al., 2021b); thus, the viscoelasticity of gluten changed. The low freezing temperature may have also led to fewer fine ice ...

A molecular reinterpretation of Alice in Wonderland reveals an ancient protein with a surprising function. In a groundbreaking discovery, researchers have found that an ancient protein still works ...

Important factors governing NPs–protein interactions include the size (curvature), surface charge, and surface state of NPs as well as coexisting ions in solvents. In this study, we focused on the ...