这篇研究通过多尺度建模与实验相结合，揭示了dna-rna杂交链置换（tmsd）反应中碱基分布对动力学参数的独特调控作用。研究发现仅通过调整固定碱基组成的置换域内碱基排列顺序，即可实现反应速率跨越4个数量级的精准调控，而热力学驱动力几乎不变。

为探究细胞如何应对细胞核内受损 RNA，Tsao 等人开展了 RNA 损伤修复相关研究。他们发现了一种新的 RNA 损伤修复途径，意外发现 RNA 烷基化可诱导 R 环和 DNA 断裂，为该领域研究提供了新方向。 已知烷基化的信使核糖核酸（mRNA ...

He uses an analogy of a city where every restaurant is given one huge recipe book — the DNA. However, it’s RNA that allows each restaurant to produce different dishes from that reference book.

If DNA is the set of genetic instructions, RNA is what reads and translates those instructions into making the proteins our cells need. RNA editing, then, is also a type of gene therapy.

Two papers published in Nature on June 26 detail how bridge RNA adapted from a transposable element can induce large-scale, genomic changes at programmable and site-specific locations within a ...

DNA and RNA methylation, initially thought to operate as distinct pathways, have been shown to interact closely, shifting our understanding of gene regulation. A team of researchers from the ...

By uncovering RNA’s previously unknown function to repair DNA damage, our findings show how RNA may directly contribute to the stability and evolution of the genome.

DNA editing uses a CRISPR-associated protein called Cas9, while editing RNA requires the use of a different CRISPR system, called type-III. In our previous work, we used type-III CRISPRs to edit ...

Researchers analyzed RNA from the 130-year-old tissue of a Tasmanian tiger, a carnivorous marsupial that went extinct nine decades ago. When you purchase through links on our site, we may earn an ...