这篇研究通过多尺度建模与实验相结合，揭示了dna-rna杂交链置换（tmsd）反应中碱基分布对动力学参数的独特调控作用。研究发现仅通过调整固定碱基组成的置换域内碱基排列顺序，即可实现反应速率跨越4个数量级的精准调控，而热力学驱动力几乎不变。

为探究 dna 甲基转移酶 1（dnmt1）相关突变导致迟发性神经退行性疾病的机制，研究人员开展了关于 dnmt1 与 rna 甲基化及线粒体功能关系的研究。 结果发现 DNMT1 可调节 RNA m5C 甲基化影响线粒体功能，为相关疾病致病机制研究提供新视角。

He uses an analogy of a city where every restaurant is given one huge recipe book — the DNA. However, it’s RNA that allows each restaurant to produce different dishes from that reference book.

Two papers published in Nature on June 26 detail how bridge RNA adapted from a transposable element can induce large-scale, genomic changes at programmable and site-specific locations within a ...

By uncovering RNA’s previously unknown function to repair DNA damage, our findings show how RNA may directly contribute to the stability and evolution of the genome.

DNA and RNA methylation, initially thought to operate as distinct pathways, have been shown to interact closely, shifting our understanding of gene regulation. A team of researchers from the ...

DNA editing uses a CRISPR-associated protein called Cas9, while editing RNA requires the use of a different CRISPR system, called type-III. In our previous work, we used type-III CRISPRs to edit ...

If DNA is the set of genetic instructions, RNA is what reads and translates those instructions into making the proteins our cells need. RNA editing, then, is also a type of gene therapy.

Cytosine is one of the four main nitrogenous bases found in DNA and RNA, along with adenine (A), guanine (G), and thymine (T) or uracil (U). It is a pyrimidine derivative, meaning it has a single-ring ...

Researchers analyzed RNA from the 130-year-old tissue of a Tasmanian tiger, a carnivorous marsupial that went extinct nine decades ago. When you purchase through links on our site, we may earn an ...