资讯

空间 RNA 组织在多种细胞过程和疾病中起关键作用,但因扰动特定亚细胞区域内源性 RNA 的技术有限,其功能影响尚未充分探索。研究人员开发 CRISPR-TO 系统,利用 RNA 引导的核酸酶失活 dCas13,实现活细胞内源性 RNA 定位的可编程控制,为相关研究提供新平台。
美国麻省总医院布里格姆基因和细胞治疗研究所 (GCTI)今天宣布启动了RNA治疗核心(RNA Therapeutics Core),这是一个同类首创的、最先进的设施和资源,用于推进RNA技术在麻省总医院布里格姆研究生态系统内外的应用。这个新的Core致力于加速探索新的治疗靶点,通过利用先进的RNA载体和递送系统,有效 ...
研究团队利用云计算与AI技术发现超16万种新RNA病毒,是已知种类的近30倍,深化了对RNA病毒多样性和演化历史的认知,并带来病毒学新发现。
The tumor suppressor p53 is a transcription factor that controls the expression of hundreds of genes. Emerging evidence suggests that the p53-induced RNA-binding protein ZMAT3 is a key splicing ...
Ribonucleic Acid (RNA) polymerase is an intermediary enzyme responsible for processing gene sequences into RNA-based genetic material that can be utilized in protein synthesis. In this article, we ...
Researchers discovered a previously unknown function of RNA, potentially opening the door to new ways to treat cancer and neurodegenerative diseases.
Octopuses and squid are masters of RNA editing while leaving DNA intact These changes could explain the intelligence and flexibility of shell-less cephalopods ...
RNA-sequencing is a technique that can examine the quantity and sequences of RNA in a sample using next-generation sequencing. Here, we look at why RNA-seq is useful, how the technique works and ...
Lipoprotein(a) is a presumed risk factor for atherosclerotic cardiovascular disease. Olpasiran is a small interfering RNA that reduces lipoprotein(a) synthesis in the liver. We conducted a randomiz ...
Elevated lipoprotein(a) concentrations are associated with atherosclerotic cardiovascular disease. The safety and efficacy of lepodisiran, an extended-duration, small interfering RNA targeting hepa ...
Orbital has raised an eye-popping $270 million for its pursuit of next-gen RNA medicines, while also managing to loop two new execs into its circle.