DEAD-box RNA helicase DDX21 is involved in both the transcription and RNA processing of ribosomal genes in human cells, sensing the transcriptional status of both RNA polymerase I and RNA ...

It has become clear that the different steps of pre-mRNA processing, from 5' capping to nuclear export, are tightly co-regulated and coordinated with transcription, translation and mRNA decay.

Overview of RNA repair – There is an emerging appreciation of the existence of “RNA repair” pathways that rely on RNA ligases to maintain or manipulate RNA structure in response to purposeful RNA ...

Widespread alterations in RNA processing (splicing, polyadenylation, decay, etc.) are common in dynamic cell states during development and malignancy. For example, many cancers harbor elevated levels ...

In a new study published in Cell Reports, researchers at the University of Freiburg reveal how a disordered protein segment helps connect two key steps of gene expression: the reading of genes and ...

Based on several lines of interesting data, the authors conclude that FMRP, though associated with stalled ribosomes, does not determine the position on the mRNAs at which ribosomes stall. Although ...

This process is carried out by the enzyme RNA polymerase, which binds to specific promoter regions on the DNA and initiates the synthesis of the complementary RNA strand. The resulting primary ...

Fred Hutch and MSK researchers showed that tumors driven by hiccups in RNA processing can't hid from the immune system. In work published in Cell, the team showed they could isolate T cells that ...

Explore the fundamentals of RNA-seq, its applications in gene expression analysis and a step-by-step protocol. ... It can also identify post-transcriptional modifications that occur during mRNA ...

Salk researchers discover how RNA processing goes awry in rare immune disease. Salk Institute. Journal Nature Communications DOI 10.1038/s41467-022-31220-8. Keywords / Life sciences ...

A University of California, Irvine-led research team has discovered intricate molecular mechanisms driving the RNA processing defects that lead to Huntington's disease and link HD with other ...

Downstream processing: The RNA encapsulation step is one of about 15 steps needed to prepare the final drug product. Downstream purification also requires scale-up and optimization.