Japan biotech xFOREST Therapeutics is teaming up with a drug discovery solutions provider in a research pact aiming to develop new RNA structure-targeted small molecule therapeutics, including mRNA ...

Department of Biomedical Engineering, McCormick School of Engineering, Northwestern University, Evanston, Illinois 60208, United States Department of Chemistry, University of Kansas, Lawrence, Kansas ...

Traditional live attenuated vaccines (LAVs) are typically developed through serial passaging or genetic engineering to introduce specific mutations or deletions. While viral RNA secondary or tertiary ...

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Creative Commons (CC): This is a Creative Commons license. Attribution (BY): Credit must be given to the creator. RNA possesses functional significance that extends beyond the transport of genetic ...

The ability to target and regulate RNA function with small molecules has vast potential, but molecular understanding of the metrics governing RNA–drug interactions is limited. Here, we present a ...

The complex and crowded cellular environment profoundly influences the structural properties and functions of biomolecules, including RNAs. In particular, biomolecular condensates represent an ...