BACKGROUND: The disruption of the blood–brain barrier (BBB) is a central pathogenic event in many central nervous system disorders. However, the mechanisms regulating BBB function remain incompletely ...

The abstract of the RENAL Replacement Therapy study concludes that in critically ill patients with acute kidney injury, treatment with higher-intensity continuous renal replacement therapy did not ...

Background The long-term trajectories of estimated glomerular filtration rate (eGFR) and their relation to early proteinuria ...

Public health recommendations suggest individuals can resume normal activities 5 days after symptom cessation. However, our study finds that full recovery can take longer, indicating that delayed ...

The start-up Function will send practically anyone to a lab for extensive medical testing, no physical required. Is that a good thing? By Kristen V. Brown As Kimberly Crisp approached middle age, ...

We report a rare case of acute neurological Behçet’s disease (neuro-BD) diagnosed concurrently with systemic Behçet’s disease ...

Following the frequent suspicions regarding the safety of cholesterol-lowering drugs in the pre-statin era,1 statins have been a recurrent object of various concerns and alarming news. For example, ...

The pathogenesis of arterial hypertension often involves a rise in systemic vascular resistance (vasoconstriction and vascular remodeling) and impairment of salt excretion in the kidney (inappropriate ...

Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells. However, to be effective, the new gene must make it into a cell's nucleus. The ...

This encyclopedic article outlines evidence-based laboratory tests that are most useful for establishing individualized health baselines while avoiding unnecessary screening. It emphasizes biological ...

Molecular imaging is redefining in vivo characterization of multiple sclerosis, a demyelinating disease with complex and heterogeneous clinical profiles. Recent advances in PET tracers enable more ...

Background Cardiogenic shock (CS) complicating acute myocardial infarction (AMI) carries high mortality. Early ...