Abstract: N 6-methyladenine (6mA) is one of the most common epigenetic modifications of DNA sequences found in both eukaryotes and prokaryotes. In prokaryotes, 6mA is closely associated with various ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. In ribosome-associated quality control (RQC), ...

A team led by UT Southwestern Medical Center scientists has identified a specific stage of neurodevelopment when differentiating neural cells produce fewer ribosomes, which are responsible for making ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Ribosome-associated protein quality control ...

We may have discovered a fundamental cause of cellular ageing that underlies many other ageing processes in cells. A study of the brains of freshwater fish called killifish has shown that, as they age ...

ABSTRACT: Gene editing technology, which allows for precise modifications to an organism’s genome, has emerged as a transformative tool in genetic engineering. This review introduces the fundamental ...

Cells rely on ribosomes to translate genetic messages into proteins, a job that underpins everything from metabolism to growth. Researchers have long believed that when ribosomes encounter an obstacle ...

Researchers have developed a new microscopy technique to observe how ribosomes function in cells. With this method, they can monitor individual ribosomes as they convert mRNA into proteins. The ...

Scientists have developed a breakthrough microscopy technique to observe ribosomes in action as they translate mRNA into proteins. This method revealed that ribosomes cooperate when encountering ...

Translation of the genetic code into proteins by ribosomes is essential for life. Due to the risk of protein misfolding, ribosomes require assistance from cotranslational processing factors, but how ...