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PPP1R3B通过糖原代谢重编程调控巨噬细胞M2极化抑制动脉粥样硬化
本文揭示了PPP1R3B通过激活STAT3信号通路,调控巨噬细胞糖原代谢重编程和M2极化,增强线粒体氧化磷酸化(OXPHOS)和胆固醇外排,显著抑制动脉粥样硬化(AS)斑块形成,为心血管疾病(ASCVD)治疗提供了新的免疫代谢靶点。 心血管疾病(CVD)是全球健康的主要 ...
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