Base editors can correct disease-causing genetic variants. After a neonate had received a diagnosis of severe carbamoyl-phosphate synthetase 1 deficiency, a disease with an estimated 50% mortality in ...

Timothy J. Wilson, Nan-Sheng Li, Jun Lu, John K. Frederiksen, Joseph A. Piccirilli, David M. J. Lilley, Olke C. Uhlenbeck Proceedings of the National Academy of Sciences of the United States of ...

In a study published in Nature Biotechnology on Aug. 28, GAO Caixia's group at the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences and her collaborators at Qi ...

Researchers from the Chinese Academy of Sciences (CAS) and their collaborators at Qi Biodesign have developed a strand-specific, CRISPR-free editing system for modifying genomes in the nucleus, ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 35 (Sep. 1, 2009), pp. 14808-14813 (6 pages) Increasing evidence indicates that an important consequence ...

Bifunctional acid−base catalysts are highly desirable for industrially relevant chemical processes. Owing to their ability to activate electrophiles and nucleophiles simultaneously, they allow the ...

Catalysis, an indispensable process in chemical engineering, requires energy, often in the form of heat, to activate the requisite chemical reactions. Photons ...