Gene therapy holds the promise of preventing and curing disease by manipulating gene expression within a patient's cells. However, to be effective, the new gene must make it into a cell's nucleus. The ...

By identifying and characterizing three key autophagy genes and tracking their responses under environmental stress, the study could help improve fish ...

For the first time, researchers have directly visualized how newly formed cellular organelles leave the endoplasmic reticulum (ER) and transition onto microtubule tracks inside living cells. This new ...

Advancements in spatial proteomics enable detailed tissue mapping, linking protein localization to disease mechanisms and ...

A research team has uncovered how the liver of Takifugu fasciatus—a commercially valuable pufferfish—activates a cellular self-protection system ...

1 Neuroscience Program, University of Scranton, Scranton, United States 2 Neuroscience Program & Department of Biology, University of Scranton, Scranton, United States The final, formatted version of ...

Proteostasis and the regulation of protein folding and sorting play a critical role in maintaining cellular homeostasis. The failure of proteostasis contributes to heart failure and aging, but, ...

Localization of ROS-producing oxidases influences the function of both the signaling mechanisms, which activate the specific oxidases, and the regulatory pathways they control. Because there appear to ...

EGA-Ploc is an advanced deep learning framework for multi-label protein subcellular localization prediction from immunohistochemistry (IHC) images. This repository contains the official implementation ...

In the evaluation of male infertility, precise assessment of sperm functional competence has surpassed the requirements of conventional semen parameters. Existing computer-aided analysis systems are ...

Interdisciplinary Science Center, State Key Laboratory of Animal Biodiversity Conservation and Integrated Pest Management, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China ...

Department of Chemistry, University of Oxford, Mansfield Road, Oxford OX1 3TA, U.K. MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, ...