While it is accepted that extracellular vesicles (EVs)-mediated transfer of microRNAs contributes to intercellular communication, the knowledge about molecular mechanisms controlling the selective and ...

Idaho National Lab partners with Clean Core to test a new thorium-based nuclear fuel that may improve safety, cut waste, and ...

Sigvotatug Vedotin is an ADC that targets integrin αvβ6-positive tumor cells. It has an engineered antibody that ensures high ...

During early drug development and preclinical development, researchers use in vitro cultured lymphocytes to induce cytokine ...

This is a useful study in the role of CHI3L1 in Kupffer cells, the macrophages of the liver, showing that CHI3L1 alters glucose regulation in obesity. Specifically, Chi3l1 protects glucose-dependent ...

Investigating how mutations in tumors alter DNA’s 3D structure—and subsequently, regulatory sequences called enhancers—can offer new treatment opportunities.

Suspected adverse reactions following chimeric antigen receptor T-cell (CAR T) treatment include more and more cases of secondary T-cell malignancies. The causality assessment of such suspected ...

A phase 1 trial evaluating FSHR-targeting CAR T cells for patients with ovarian cancer has dosed the first patient in its third cohort.

KLF7 is known to promote T cell proliferation. When analyzing samples from LBCL patients treated with CAR-T therapy, they found that the CAR-T cells with higher levels of KLF7 were associated with ...

By Dr. Chinta Sidharthan New research highlights how elevated levels of the iron-regulating hormone hepcidin contribute to ...