Immune low-response states significantly impact the effectiveness of immunotherapy in cancer treatment. These states ...

This article explores how single-cell multiomics and spatial transcriptomics are illuminating early pregnancy, uncovering ...

The liver is remarkable for its ability to regenerate after injury, yet when this process fails, acute liver failure (ALF) carries devastating outcomes. Traditional research methods, reliant on bulk ...

Initially, cells are dissociated from liver tissues into single-cell suspensions using in vivo enzymatic perfusion or ex vivo digestion methods. The cells of interest are then enriched from the ...

A comprehensive review article titled “Bioinformatics perspectives on transcriptomics: A comprehensive review of bulk and single-cell RNA sequencing analyses,” published in Quantitative Biology, ...

Scaling up single-cell sequencing studies allows scientists to uncover rare cell types, better understand disease states, and track cellular changes over time. However, processing, assaying, and ...

Spatial transcriptomics is a technique that provides information about gene expression patterns within intact tissues. This technology employs various methodologies, including in situ sequencing (ISS) ...