During early drug development and preclinical development, researchers use in vitro cultured lymphocytes to induce cytokine ...

The study reviews CAR-T cell advancements in lymphoma treatment, addressing T cell exhaustion and tumor immune evasion with ...

Tumor cells often secrete lncRNAs into the surrounding stroma, where they can bind to receptors on stromal cells and alter their behavior, thus reinforcing tumor cell growth and survival.

T cells are a natural part of the immune system designed to fight infections and cancer, but in conditions like blood cancer, they may not be able to eliminate malignant cells, according to Dr.

CAR T cells expressing any of these chimeric cytokine receptors had superior antitumor activity against multiple types of cancer in both cell lines and mouse models compared to conventional CAR T ...

Host mice deficient in IFNγ receptors showed uncontrolled leptomeningeal tumor growth, yet subcutaneous or orthotopic tumors remained unchanged. T cells emerged as the primary source of IFNγ ...

That led them to develop new receptors, now called SNIPRs (synthetic intramembrane proteolysis receptors), which can bind to soluble, or free-floating, molecules in the environment around a cell.

To use modern machine learning approaches to enhance and automate the feature extraction from the longitudinal circulating tumor DNA (ctDNA) data and to improve the prediction of survival and disease ...

The breakthrough, appearing in Nature on Nov. 14, revolves around engineered receptors on the surface of cells that can sense molecules in the surrounding environment and, in response, change the ...

Every cell has a story: Tumor and immune cell interactions within craniopharyngiomas. ScienceDaily . Retrieved June 11, 2025 from www.sciencedaily.com / releases / 2024 / 12 / 241216125920.htm ...