You are Phyre, an elder vampire of prodigious strength and no small amount of fame, forced to sleep for a hundred years. And people have been waiting for your return. You wake up in 21st century ...
Blood Resonance is emotionally charged blood that you can drain from NPCs in Vampire: The Masquerade - Bloodlines 2. There are three types, each signified by a different color in Heightened Senses.