UMD researchers have discovered key mechanisms in gene regulation that could improve the design of RNA-based medicines.

Researchers studying gene expression have access to vast amounts of data from cells or tissues. This is thanks to advances in ...

2025年2月4日发表在《eLife》杂志上的一项新研究可能会导致基于rna的药物开发取得突破。马里兰大学的研究人员使用微型线虫作为模型来研究dsRNA分子如何自然进入细胞并影响许多后代。研究小组发现了dsRNA进入线虫细胞的多种途径，这一发现可能有助于改善人类的药物输送方法。

这在很大程度上受到了过去 60 多年关于 RNA 结构的错误观念的影响。王运星实验室的研究结果颠覆和更正了这些观念，并提出了用“准等能量”分子构象转换概念，来概括全新的 RNA 分子在溶液中的行为。

马里兰大学的研究人员揭示了基因调控的关键机制，这一发现有望改进基于RNA的药物设计。近年来，RNA疫苗和双链RNA（dsRNA）疗法的成功证明了基于RNA的药物在对抗人类疾病方面的巨大潜力。然而，如何将这些RNA分子有效地输送到细胞中仍然是一个重大挑战。

Preclinical studies have shown their potential to reduce inflammation and modulate immune responses in diseases like rheumatoid arthritis and lupus.

UMD researchers uncover key mechanisms in gene regulation that may lead to better design of RNA-based medicines.

1958年，弗朗西斯・克里克提出了中心法则，提出遗传信息从 DNA 转录为 RNA，再经翻译指导蛋白质合成，随后蛋白质参与生命活动这一流程，看似一气呵成，实则存在问题。 若仔细观察，便会发觉此流程不够简洁，RNA ...

Discover the importance of vision, genetic eye disorders, and RNA-based therapies for precision treatment in India and ...

Many people follow the golden rules of avoiding direct sunlight between the hours of noon and 3 p.m., staying in […] ...

Applied DNA Sciences, Inc. (NASDAQ:APDN) (”Applied DNA” or the “Company”), a leader in PCR-based DNA technologies, today issued a reminder to its shareholders to vote ahead of a reconvening of a ...

An RNA platform successfully predicted fetal growth restriction within the second trimester of pregnancy, independent of ...