Modern life makes us tired, right? But research from societies in Africa and South America suggests people in the ancient ...
Modern life makes us tired, right? But research from societies in Africa and South America suggests people in the ancient ...
IL - 12 驱动淀粉样脑的病理 :通过基因敲除实验,研究人员发现删除 IL - 12 特异性受体基因 Il12rb2 可显著降低 APPPS1 小鼠的淀粉样蛋白(Aβ)负担,而删除 IL - 23 受体则没有效果。这表明在淀粉样脑环境中,IL - 12 是驱动 AD 病理的关键因素。
“我们进行了多种记忆测试,药物在所有测试中都显示出改善效果。”Lipton说。“它不仅减缓了衰退,还几乎恢复到正常水平。”组织分析还显示突触密度增加,磷酸化tau蛋白聚集和淀粉样β蛋白斑块的形成减少。