Sample loss has been a persistent problem in cryo-EM, a high-tech method for creating 3D models of molecules that reveal their inner structures. It occurs during an essential step of imaging ...

Most people have witnessed -- or rather smelled -- when a protein enzyme called sulfite reductase works its magic. This enzyme catalyzes the chemical reduction of sulfite to hydrogen sulfide. Hydrogen ...

A collaborative team from the Rosalind Franklin Institute, the University of Oxford, and Diamond Light Source has developed a breakthrough method that makes it possible to image very small proteins ...

In order to expand access to cutting-edge research technology, the University of California, Santa Cruz, is welcoming institutions in the United States and abroad to use its powerful ...

Structural biology is used to understand the three-dimensional shape of biological molecules and how their shape enables them to function both inside and outside of cells. Furthermore, the ...

Researchers from the National University of Singapore (NUS) have successfully applied cryo-electron microscopy (cryo-EM) to unveil the molecular structures of critical protein machines that transport ...

Chromatin remodeling plays a vital role in gene regulation, affecting how DNA is accessed. Disruptions in this process can also lead to cancer and other diseases. To better understand how chromatin ...

RAB7A plays a central role in the final stages of autophagy, facilitating autophagosome-lysosome fusion, lysosome positioning, and cargo degradation. Its activation by guanine nucleotide exchange ...

The Yale labs of Craig Roy and Jun Liu have harnessed the power of cryo-EM to solve a 30-year mystery of how the Legionella bacteria works. The findings represent the next steps in the search for new ...

Particles (encircled in green) are spaced at a distance from the noise surrounding the nanobeads (purple), which would otherwise obscure them. Sample loss has been a persistent problem in cryo-EM, a ...