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定制与非定制噬菌体疗法在耐药细菌感染患者中的临床疗效与安全性 ...
为解决耐药/难治性细菌感染患者高死亡率问题,研究人员开展噬菌体疗法 (PT)定制策略的系统评价,纳入130项研究 (1115例患者)显示总体临床改善率72% (I2 88%),定制生产组成功率最高 (79-87%)但存在治疗延迟,证实PT具有良好安全性且多途径给药可提升疗效,为AMR (抗菌素耐药性)时代提供重要治疗选择。
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