Data on the relationship between ribosome biogenesis and p53 function indicate that the tumour suppressor can be activated by either nucleolar disruption or ribosomal protein defects. However, there ...

2016 年8 月北京大学生命科学学院郑晓峰课题组在《Nature Communications》杂志在线发表了题为“The ATPase hCINAP regulates 18S rRNAprocessing and is essential for embryogenesis and tumor growth”的研究论文。首次揭示了hCINAP 蛋白调控人类细胞18S rRNA ...

Many DNA repair proteins have additional functions other than their roles in DNA repair. In addition to catalyzing PCNA polyubiquitylation in response to the stalling of DNA replication, SHPRH has the ...

In eukaryotes, there are four rRNAs associated with ribosomes; these are the 18S, 5.8S, 28s, and 5S rRNAs. Production of the first three occurs within the nucleolus, whereas 5S rRNA production occurs ...

Evaluation of baseline BRAF V600E mutation in circulating tumor DNA and efficacy response from the BEACON study. This is an ASCO Meeting Abstract from the 2022 ASCO Gastrointestinal Cancers Symposium.

Two key sequencing techniques are no longer at odds, thanks to an international effort led by scientists at University of California (UC) San Diego. The researchers have developed a reference database ...

Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, No. 14 (Jul. 15, 1992), pp. 6535-6539 (5 pages) A vector-transformation system is described that permits ...

A research group led by Prof. Guang Shouhong from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences, collaborating with Prof. Feng Xuezhu from the First ...

Next-generation sequencing of the bacterial assemblages that inhabit a corpse throughout decomposition improve time-of-death estimates. In this webinar, learn how next-gen CAR-T design targets solid ...