Introduction: High-quality randomised controlled trials (RCTs) provide the most reliable evidence on the comparative efficacy of new medicines. However, non-randomised studies (NRS) are increasingly ...

Journal clubs, typically involving a group of health professionals or trainees who discuss recent study findings, have long ...

Introduction. The concepts of evidence-based medicine are evolving as limitations of early models are addressed. In this editorial, we present a new model for evidence-based clinical decision making ...

‘Big data’ is defined by ‘7 V’s’: volume (most frequently cited1), velocity, veracity, variety, volatility, validity and value. In healthcare, ‘big data’ is associated with a step-change in the way ...

Qualitative evidence allows researchers to analyse human experience and provides useful exploratory insights into experiential matters and meaning, often explaining the ‘how’ and ‘why’. As we have ...

Introduction. The burden of death due to firearms is an ongoing public health problem in the USA. US men had a 21% life expectancy loss due to firearms compared with men from other countries.1 In 2016 ...

The effects of statins in the elderly are better informed by absolute effects and the number needed to evaluate the benefit to harm balance. Such an approach enables patients to make more informative ...

Objectives To describe the proportion of transvaginal ultrasounds performed in a University Hospital of Buenos Aires (Argentina), requested upon a health check. Method Cross-sectional study of a ...

This article is part of a series of articles featuring the Catalogue of Bias introduced in this volume of BMJ Evidence-Based Medicine that describes attrition bias and outlines its potential impact on ...

Alcohol-based hand sanitisers, if ingested, can have toxic effects and may even be lethal. Preventable deaths from ingesting hand sanitisers have been identified. This article describes two Prevent ...

Commentary on : Gerber JS, Ross RK, Bryan M, et al . Association of Broad- vs Narrow-Spectrum Antibiotics With Treatment Failure, Adverse Events, and Quality of Life in Children With Acute Respiratory ...