The increasing knowledge of barrier tissue-resident memory macrophages and trained innate immunity (TII) will help develop both nontarget-specific and target-specific TII-based vaccine strategies.

A novel connectomics approach reveals synaptic connectivity differences between narrowly and broadly tuned olfactory glomeruli in Drosophila melanogaster, providing new insights into glomerular ...

Blood flow and a hormone called ghrelin help new neurons travel to where they are meant to be in the brain of adult mice.

Alternative splicing exhibits lineage-specific variability, with mammals and birds reaching the highest levels despite conserved intron-rich architectures, while unicellular eukaryotes and prokaryotes ...

The impact of IL10 mutation in birds highlights the intrinsic compromise between effective elimination of a pathogen and damage to the host.

This valuable study presents a novel approach to enhance the therapeutic potential of mesenchymal stromal cells (MSCs) by genetically modifying their glycogen synthesis pathway, resulting in increased ...

This study addresses an important question in liver biology: how zonal hepatocytes balance survival and proliferation following injury; using spatial transcriptomics, mechanistic perturbations, and ...

The new program is validated in a set of clinical pedigrees demonstrating its practical accuracy and relevance to the field. Collectively, the data are compelling and support the major conclusions of ...

Transient intrinsic properties of young neurons enable fast learning and support memory stability as the neurons mature, offering a coherent view of the function of adult neurogenesis in olfaction.

Altmetric provides a collated score for online attention across various platforms and media. See more details Human fertility is suboptimal, partly due to error-prone divisions in early ...

A study that monitored the expression and function of designer receptors called DREADDs in macaque monkeys for a period of three years demonstrates that they are effective in long-term studies of ...

High-content high-resolution microscopy coupled with deep learning-based analysis reveals novel phenotypes at the single-cell level during Shigella infection.