An evolutionary perspective on immune priming across plants and invertebrates highlights the roles of microbiomes and epigenetic regulation in shaping innate immune memory with promising applications ...

Cryo-EM and electrophysiology reveal the mechanism of SK2 channel modulation by the bee toxin apamin and small molecules, providing insights that enable the rational design of targeted SK2 channel ...

Songbird HVC sequences arise from a balance of ionic currents and structured inhibition, providing a mechanistic framework for understanding cortical sequence generation.

This useful study demonstrates that microsaccade direction primarily indexes shifts rather than the maintenance of covert spatial attention, offering a focused interpretation that may help reconcile ...

This study presents a large, systematically curated catalog of non-canonical open reading frames (ncORFs) in human and mouse by reanalyzing nearly 400 Ribo-seq datasets using a standardized pipeline; ...

Amino acids that were abundant since the prebiotic era are enriched in protein binding sites of the most ancient coenzymes, supporting the plausibility of an early coenzyme–peptide world.

eLife reviews research spanning allergy, immunity and immunoregulation, inflammation and T-cell receptor signalling. Learn more about what we review and sign up for the latest research.

We highlight recent developments in eLife’s equity, diversity and inclusion framework and what steps we plan to take next ...

A new method for tracking the activity of individual neurons day after day in the growing brain has revealed a key developmental transition in neuronal activity.

This manuscript makes a valuable contribution to the concept of fragility of meta-analyses via the so-called 'ellipse of insignificance for meta-analyses' (EOIMETA). The strength of evidence is solid, ...

eLife reviews research covering virology, bacteriology and mycology. Learn more about what we review and sign up for the latest research.

Purkinje cell subpopulations have varying vulnerability to age-related neurodegeneration, creating a striped pattern of cell loss that reflects the developmental, anatomical, and functional ...