Subepithelial lesions (SLEs) are often detected incidentally during endoscopic examination. They represent a heterogeneous ...

Background The risk of developing advanced neoplasia (AN; colorectal cancer and/or high-grade dysplasia) in ulcerative colitis (UC) patients with a low-grade dysplasia (LGD) lesion is variable and ...

Background With the development of micromanufacturing and 3D printing technologies, gut-on-a-chip provides a new method for studying intestinal diseases in vitro. Based on intestinal functions, gut-on ...

Introduction Coeliac disease (CD) is a common immune-mediated condition driven by aberrant adaptive CD4+ T cell responses to gluten. The cytotoxic CD8+ and γδ+ T cell response in the epithelium is ...

Introduction Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease, with type 2 diabetes mellitus (T2DM) as a major predictor. Insulin resistance and chronic ...

Correspondence to Dr Séverine Vermeire, Department of Chronic Diseases, Metabolism and Ageing - TARGID, KU Leuven, Leuven B-3000, Belgium; severine.vermeire{at}uzleuven.be IBD is a complex ...

Objective The pathogenesis of UC relates to gut microbiota dysbiosis. We postulate that alterations in the viral community populating the intestinal mucosa play an important role in UC pathogenesis.

2 Key Laboratory of Prevention, Diagnosis and Therapy of Upper Gastrointestinal Cancer of Zhejiang Province, Hangzhou, China Objective Metabolic biomarkers are expected to decode the phenotype of ...

Objective The extent to which tryptophan (Trp) metabolism alterations explain or influence the outcome of inflammatory bowel diseases (IBDs) is still unclear. However, several Trp metabolism ...

Objective Follistatin-like protein 1 (FSTL1) is widely recognised as a secreted glycoprotein, but its role in modulating macrophage-related inflammation during liver fibrosis has not been documented.

Objective Despite significant progresses in imaging and pathological evaluation, early differentiation between benign and malignant biliary strictures remains challenging. Endoscopic retrograde ...

Correspondence to Dr Chia-Chen Lu, Department of Respiratory Therapy, Fu Jen Catholic University, New Taipei City, Taiwan; chiachen.lulu{at}gmail.com Objective Chronic obstructive pulmonary disease ...