Background Amyloid-related imaging abnormalities due to oedema (ARIA-E) or haemosiderin deposits (ARIA-H) have been associated with the use of monoclonal antibodies, such as lecanemab, for the ...

Background Evidence of best practice for long term physical activity Huntington’s disease (HD) is lacking, due in part, to inherent challenges in the delivery and evaluation of such life-style ...

Standardization, innovation, and multidisciplinary teamwork could be the key On 19 Dec 2024, the Journal of Neurology, Neurosurgery, and Psychiatry (JNNP), in partnership with the Department of ...

Background Benign multiple sclerosis (MS), characterised by minimal disability despite long disease duration, remains poorly understood in terms of its determinants and prognostic implications. While ...

Background Total bilirubin (TBIL) has antioxidant and anti-inflammatory properties. This study aimed to determine whether elevated TBIL could modify the association between diabetes and stroke. Method ...

Enroll-HD is a global research platform. Key elements of the platform’s infrastructure include global study management and governance, standardised informed consent forms (ICFs) and site contracts, ...

Objectives Cognitive flexibility, which is key for adaptive decision-making, engages prefrontal cortex (PFC)-striatal circuitry and is impaired in both manifest and premanifest Huntington’s disease ...

Background Unilateral magnetic resonance-guided focused ultrasound (FUS) thalamotomy is efficacious for the treatment of medically refractory essential tremor (ET). Viability of bilateral FUS ablation ...

Objective Inflammation is a key pathological hallmark in amyotrophic lateral sclerosis (ALS), which seems to be linked to the disease progression. It is not clear what the added diagnostic and ...

Spinal arachnoiditis is a rare condition. Eighty cases, diagnosed during a period when 7600 spinal contrast investigations were undertaken, have been reviewed. The majority had suffered a previous ...

Parkinson’s disease seems to occur more commonly in men than women based primarily on studies of death rates and prevalence. In recent years, several population based incidence studies of Parkinson’s ...