Background Systemic lupus erythematosus (SLE) is an inflammatory disease with complex genetic underpinnings. SLE association at 2p22.3 is one of the most consistently replicated SLE signals. We ...

Objectives Nearly 20% of pregnancies in patients with SLE result in an adverse pregnancy outcome (APO). We previously developed an APO prediction model using logistic regression and data from ...

Objective To assess the economic burden of patients with SLE by disease severity in the USA 1 year before and after diagnosis.Methods Patients aged ≥18 years with a first SLE diagnosis (index date) ...

Objective BAFF and APRIL signal through TACI, BCMA, and/or BAFF-R, and play important roles in the activation, differentiation, and/or survival of B cells, particularly antibody-secreting cells, as ...

Objective It is still a matter of debate whether low-dose acetylsalicylic acid (LDASA) should be prescribed to all patients with SLE during pregnancy. This study aimed at investigating the impact of ...

Objective Early prediction of long-term outcomes in patients with systemic lupus erythematosus (SLE) remains a great challenge in clinical practice. Our study aims to develop and validate predictive ...

Objectives This study aimed to investigate serum glutathione reductase (GR) levels in patients with SLE and to assess its association with disease activity.Methods The retrospective study collected ...

Conclusion We are successfully using a “rare disease study” approach to conduct the first trial of a biologic therapy to prevent pregnancy complications in women with APS and LAC. Certolizumab appears ...

Background SLE is a complex autoimmune disease with heterogeneous manifestations and unpredictable outcomes. Early diagnosis is challenging due to non-specific symptoms, and current treatments only ...

Objective Lupus nephritis (LN) is characterised by renal endothelial dysfunction, which contributes to progressive kidney injury. Endothelial nitric oxide synthase (eNOS) plays a modulating role in LN ...

Objective We aim to assess the cerebral oxygen extraction fraction (OEF) changes in patients with systemic lupus erythematosus (SLE) and neuropsychiatric SLE (NPSLE) by using an MRI-based technique ...

Introduction. SLE is a common chronic autoimmune disease that often affects multiple organs, including the kidneys, with up to 60% of patients developing lupus nephritis (LN).1 2 LN is among the most ...