Prostate cancer (PCa) is the second most frequently occurring cancer and the fifth leading cause of cancer mortality among men worldwide in 2022 (Bray et al, 2024).Androgen receptor (AR) is considered ...

Rheumatoid arthritis (RA) is associated with heart and lung dysfunction. Current therapies fail to attenuate such complications. Here, we identify formyl-peptide receptor type 2 (FPR2) as a ...

Each journal is staffed by professional editors who work in collaboration with one another and our international Editorial Advisory Boards of leading scientists. Please feel free to contact any of the ...

EMBO Press publishes five scientific journals: The EMBO Journal - Submit here The EMBO Journal has been EMBO's flagship publication for 40 years. With a scope that spans all areas of molecular biology ...

N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

STUB1 encodes the carboxyl terminus of the Hsc70-interacting protein (CHIP), which has dual-molecular chaperone function and E3 ubiquitin ligase activity (Narayan et al, 2015; Stankiewicz et al, 2010; ...

The mammary gland is composed of a ductal tree branching into secondary and tertiary ducts that end in terminal ductal lobular units (TDLUs), considered the functional units of the mature human ...

In this study, using C. elegans and human cell lines, we characterized the physiological effects of thiol reductive stress. Because thiol antioxidants result in the increased expression of rips‐1 ...

The ubiquitin system is an integral part of cellular responses to environmental changes. The post‐translational modification of proteins with ubiquitin modulates virtually every cellular pathway and ...

Astrocytes are generated from radial glial cells (RGCs) in the ventricular zone during brain development (Kriegstein and Alvarez-Buylla, 2009; Lin et al, 2021).In the dorsal neocortex, RGCs express ...

ITM2B/BRI2 mutations cause Alzheimer’s Disease (AD)-related dementias. We observe heightened ITM2B/BRI2 expression in microglia, a pivotal cell type in AD due to risk-increasing variants in the ...

Signal recognition particle (SRP) is a ubiquitous ribonucleoprotein particle found in all three domains of life, but its complexity has increased considerably during evolution (Walter and Johnson, ...