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Technological advances in genomics and imaging have led to an explosion of molecular and cellular profiling data from large numbers of samples. This rapid increase in biological data dimension and ...

While such loss‐of‐function mutagenesis is a powerful approach to the genetic dissection of signal pathways (Glazebrook, 2001), many genes cannot be uncovered in this way because of lethal effects or ...

Human Tsg101 plays key roles in HIV budding and in cellular vacuolar protein sorting (VPS). In performing these functions, Tsg101 binds both ubiquitin (Ub) and the PTAP tetrapeptide ‘late domain’ ...

Schwann cells are a regenerative cell type. Following nerve injury, a differentiated myelinating Schwann cell can dedifferentiate and regain the potential to proliferate. These cells then ...

Atg8 is conjugated to phosphatidylethanolamine (PE) by ubiquitin‐like conjugation reactions. Atg8 has at least two functions in autophagy: membrane biogenesis and target recognition. Regulation of PE ...

The 5′ capping of mammalian pre‐mRNAs is initiated by RNA triphosphatase, a member of the cysteine phosphatase superfamily. Here we report the 1.65 Å crystal structure of mouse RNA triphosphatase, ...

Autophagy is a major pathway for delivery of proteins and organelles to lysosomes/the vacuole, where they are degraded and recycled. Autophagy plays an essential role in differentiation and ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Genome‐, transcriptome‐ and proteome‐wide ...

Fluid shear stress is a critical determinant of vascular remodeling and atherogenesis. Both integrins and the small GTPase Rho are implicated in endothelial cell responses to shear but the mechanisms ...

In E. coli, the Cascade complex alone is able to generate crRNA but requires Cas3 to achieve immunity against foreign DNA (Brouns et al, 2008). Hence, Cas3 appears to be a key protein of CRISPR system ...

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