Macrolides bind reversibly to 23S ribosomal RNA (rRNA) of the 50S subunit of bacterial ribosome inhibiting RNA-dependent protein synthesis. Clindamycin (a lincosamide) at subgrowth inhibitory ...
Large Subunit rRNAs: The large subunit in prokaryotes contains the 23S and 5S rRNAs, while in eukaryotes, it contains the 28S, 5.8S, and 5S rRNAs. These rRNAs play a role in peptide bond formation and ...
pylori infections, is often caused by point mutations in the 23S ribosomal RNA coding gene of the bacterium. This resistance necessitates repeated diagnostic tests and multiple courses of ...
in domain V of the 23s rRNA of the 50S subunit. ≥18yrs: Tabs: Swallow whole. Take with water at least 1hr before or 2hrs after a meal. 600mg every 12hrs for 5 days. Moderate or severe hepatic ...
Oxazolidinone Linezolid Binds to 23S rRNA of the 50S ribosomal subunits and prevents formation of the 70S initiation complex Mutation(s) in the 23S rRNA ↓↓↓ Aminoglycoside Gentamicin ...