The San Francisco 49ers take on the Houston Texans at 10 a.m. PT on Sunday, Oct. 26 at NRG Stadium in Houston.

The San Francisco 49ers and Tampa Bay Buccaneers could both use more firepower along the edge. The 49ers are dealing with multiple injuries at the position. Not only is Nick Bosa out for the season ...

Don't let the 2-4 record of the Houston Texans fool you. That is a fairly strong team the San Francisco 49ers will be taking ...

The 49ers welcomed Special Olympics athletes for an unforgettable day of flag football, teamwork, and celebration bringing ...

If the 49ers win Sunday in Houston, they'll match their overall win total from last season and they'll be alone atop the NFC ...

The NFL has announced a punishment for a San Francisco 49ers star following the team’s recent loss to the Tampa Bay ...

The San Francisco 49ers need a linebacker and it just so happens their old friend, Houston Texans head coach DeMeco Ryans, ...

He’s on pace to finish the season with 1,129 rushing yards and seven scores and 129 catches for 1,253 yards and seven ...

San Francisco 49ers head coach Kyle Shanahan detailed the team's latest injury report, opened up about his pregame speeches, ...

As the Tampa Bay Buccaneers prepare for another heated NFC South battle with the New Orleans Saints, the defense once again ...

The Atlanta Falcons traveled to Santa Clara, California to take on the San Francisco 49ers on "Sunday Night Football." Here's ...

Kickoff from Ford Field is set for 7 p.m. ET. Detroit is a 6-point favorite in the latest Buccaneers vs. Lions odds, and the ...