Coadministration of multiple doses of 10 mg amlodipine with 80 mg simvastatin resulted in a 77% increase in exposure to simvastatin compared with simvastatin alone. 29 However, coadministration of ...

Amlodipine is characterised by a long elimination half-life of 35–50 hours, a bioavailability of 64–80%, and peak plasma concentrations after 6–12 hours.