Tumour necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) receptors (TRAILR1 and TRAILR2) are promising targets for cancer therapy: both recombinant TRAIL and monoclonal antibodies ...

These results identify for the first time the AHR-E2F1-CHK1 axis as a novel anti-apoptotic pathway in KC, which may represent a suitable target for chemoprevention of non-melanoma skin cancer.

Methods: Four different EC cell lines, which are known to exhibit resistance to TRAIL/FAS-induced apoptosis (Ishikawa, KLE, HEC1A, and RL-95) were exposed to various pharmacologic substances that ...

Background: The MAPK pathway is a crucial regulator of cell proliferation, survival, and resistance to apoptosis. Hyperactivation of this pathway due to mutations in KRAS have been reported in up to ...

“BAKX instead is successfully activating pro-apoptotic proteins such as BAX and BAK using a combination of unsurpassed target and pathway knowledge, deep expertise in conformationally dynamic ...

Above, from left: Xu Luo, Xiaodong Wang, and Imawati Budihardjo. In apoptosis, death signals from outside a cell are conveyed to various organelles inside a cell through an intricate network of ...

The PD-1 pathway plays an essential role in maintaining immunologic self-tolerance. However, cancers can subvert the role of this pathway and blind the immune system to their presence. The molecula ...

AK2 regulates etoposide- and staurosporine-induced cell death, according to research in Nature Cell Biology. South Korean scientists found that adenylate kinase 2 (AK2) activates an apoptotic ...

A pathway that appears to be unique to the liver involves toll-like receptor 4 (TLR4) 47; TLR4 is activated on the surface of stellate cells by intestinal bacterial lipopolysaccharides derived ...