LC3-II is used as a marker of autophagy because its lipidation and specific recruitment to autophagosomes provides a shift from diffuse to punctate staining of the protein and increases its ...

LC3 is required for canonical and non-canonical autophagy. Here, the authors uncover LAPTIN, a function of LC3 triggered by integrin LFA1 outside-in signaling, which activates AMPK to drive the co ...