生命科学Life science本期Trends in Cell Biology特刊深入探讨了核糖体功能、翻译机制和细胞健康之间错综复杂的关系。这些论文全面概述了核糖体和翻译在各种生物过程中发挥的关键作用，及其对健康和疾病的影响。有兴趣在Trends ...

When Steven Benner set out to re-engineer genetic molecules, he didn't think much of DNA. “The first thing you realize is that it is a stupid design,” says Benner, a biological chemist at the ...

在基因组研究领域，转座元件（TEs）与宿主基因组的关系一直备受关注。为探究巨型基因组中 TEs 和宿主抑制如何导致大量 DNA 的添加，研究人员分析了 6 种蝾螈基因组。结果发现二者关系无明显规律，这为理解基因组进化提供了新方向。

The research reveals how targeting the KMT2D gene could help correct oral disorders and prevent craniofacial birth defects.

为解决这一难题，来自梅奥诊所的一个研究团队在一项新的研究中开发了一种名为BACDAC的新型计算工具，旨在揭示这些难以捉摸的基因组模式。该工具通过全基因组测序技术，即使在纯度低或覆盖率低的样本中，也能帮助识别基因组不稳定性的迹象。此外，它还可能帮助临床医生更准确地预测肿瘤的行为，并指导更个性化的治疗选择。相关研究结果发表在 Genome Biology 杂志上。

本文详细介绍了构建质粒 DNA 疫苗的原理，同时着重阐述了获取 DNA 构建体的新技术。像微型环状 DNA（minicircular DNA）、MIDGE DNA 和 Doggybone TM DNA 等。 这些新型 DNA 疫苗意义重大，它们仅包含激活免疫反应的关键要素，完全摒弃了在细菌细胞中生产质粒 DNA 所需的序列，比如抗生素抗性基因。

DNA in the nucleus of mammalian cells is extensively associated with proteins. Potential anticancer agents can access, recognize and alkylate nucleosomal DNA, even at sites that seem completely ...

A piece of chewed birch bark tar gum unearthed in western Sweden has unlocked a window into ancient life, revealing the ...

In March, he received the prestigious American Association for Dental, Oral and Craniofacial Research (AADOCR) Joseph Lister ...

The earliest ever human DNA from Scandinavia is set to help humans know about the elusive people who first settled in the ...

Peering inside cells has been an integral part of biology ever since the 17th century, when cells were discovered under a microscope. But even with advances in light and electron microscopy ...