Hidden within our bones, marrow sustains life by producing billions of blood cells daily, from oxygen-carrying red cells to immune-boosting white cells.
Healthy bone marrow is essential to living. Sickle cell anemia, leukemia, lymphoma, and aplastic anemia are some life-threatening diseases that occur when the bone marrow fails to function properly.
Bone marrow mesenchymal stromal cells (BMSCs), identified as pericytes comprising the hematopoietic niche, are a group of heterogeneous cells composed of multipotent stem cells, including ...
Bone-marrow-derived multipotent progenitor ... which is enhanced by interferon-γ released by activated T cells. MSCs also impair B-cell functions, such as antibody production.