Background Rheumatoid arthritis (RA) and other types of inflammatory arthritis follow a characteristic anatomical pattern of joint involvement. We have recently shown that local synovial stromal cells ...

Both sorafenib and interleukin-27 (IL-27) are antineoplastic drugs. This study aimed to investigate the synergistic effect of these two drugs on bladder cancer cells. HTB-9 and T24 cells were ...

Not developing potency assays and gaining knowledge about MOAs early in the drug development process not only can break ATMP success but can cause costs and delays that lead to company closures.

Methods: We used male and female EC-specific tamoxifen-inducible OCT4 knockout and EC-lineage tracing (EC-OCT4 KO) mice to study the role of OCT4 in non-atherosclerotic conditions leading to ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Upon replication fork stalling, the RPA-coated ...

Large scale cell movements occur during gastrulation in vertebrate embryos but their role in this major morphogenetic transition in formation of the body plan is poorly understood. Using the chick ...

Background and Purpose: Benzimidazoles have attracted much attention over the last few decades due to their broad-spectrum pharmacological properties. Increasing evidence is showing the potential use ...