Supercomputer draws molecular blueprint for repairing damaged DNA
Sunburns and aging skin are obvious effects of exposure to harmful UV rays, tobacco smoke and other carcinogens. But the ...
Scientists Capture First-Ever Images of Cancer’s Covert DNA Repair Strategy
A new structural blueprint paves the way for improved targeting of cancer cells, particularly those with BRCA1 and BRCA2 ...
Scientists Just Discovered an RNA That Repairs DNA Damage – And It’s a Game-Changer
Our DNA is constantly under threat — from cell division errors to external factors like sunlight and smoking. Fortunately, ...
Nature3 年
Double-strand DNA breaks articles from across Nature Portfolio
A double-strand DNA break (DSB ... microscopy to show how the helicase domain of DNA polymerase θ aligns broken DNA strands by matching short sequences, a process linked to cancer.
Mirage News2 小时
Summit Supercomputer Maps DNA Repair Blueprint
The Summit supercomputer revealed how damaged strands of DNA are surgically repaired by a molecular pathway called nucleotide ...
Why aged oocytes struggle to repair DNA damage
A woman's egg cells are already formed in her body before she is born. However, with increasing age, DNA damage accumulates ...
mskcc.org6 年
DNA Damage Recognition and Repair by DNA Ligases
The NTase domain binds to the broken DNA strands at and flanking the nick, the OB domain contacts the continuous template strand surrounding the nick, and the HhH domain binds both strands across the ...
EurekAlert!8 天
How a crucial DNA repair protein works—and what it means for cancer treatment (IMAGE)
The Pol-theta enzyme (blue) joins two parts of a broken DNA strand (yellow). This process is mutagenic and can give rise to cancer.
来自MSN9 天
How a crucial DNA repair protein works—and what it means for cancer treatment
Once a matching sequence is found, Pol-theta holds the broken DNA strands together so that they can be stitched together ...
Medical Xpress9 天
How a crucial DNA repair protein works—and what it means for cancer treatment
Once a matching sequence is found, Pol-theta holds the broken DNA strands together ... "Human polymerase θ helicase positions DNA microhomologies for double-strand break repair," include Yonghong ...
EurekAlert!9 天
How a crucial DNA repair protein works—and what it means for cancer treatment
The Pol-theta enzyme (blue) joins two parts of a broken DNA strand (yellow). This process is mutagenic and can give rise to cancer. LA JOLLA, CA—DNA repair proteins act like the body’s editors ...