The platform enables direct, unbiased genome-wide identification and quantification of the exact position of double strand ...

Broken String Biosciences ("Broken String"), a leader in advancing gene editing safety, today opened its Catalyst Early ...

Cells were irradiated on ice in 150-mm Petri dishes using a 137 Cs source at a dose rate of 3.65 Gy/min. The results suggest that, for the radiosensitive patient, misrepair of broken DNA ends in ...

A double-strand DNA break (DSB) occurs or arises when both strands of the DNA duplex are severed, often as the result of ionizing radiation. They are particularly deleterious as the DNA ends can ...

High-tech laboratory environment, genetic analysis and research. High quality 4k footage Dna disorder concept. Abstract dna strand structure on damage process, tiny parts are slowly flowing away.

The RNA Institute, University at Albany, State University of New York, Albany, New York 12222, United States Department of Nanoscale Science and Engineering, University at Albany, State University of ...

HR mechanisms generally achieve accurate repair of DNA damage. Double-stranded breaks are repaired by HR or by end-joining mechanisms, which can be non-homologous. Broken replication forks with ...

Bakuchiol inhibited DNA replication and activated the checkpoint kinase CHK1 by targeting DNA polymerases. Isobavachalcone interfered with DNA double-strand break (DSB) repair by inhibiting the ...

The cause is related to expansion of repeating DNA units, in which specific strings of genetic code—in this case, a series of cytosine-adenine-guanine nucleotides, or CAG, on one strand of the ...