Rather than being famous only in the gene editing field, by revealing the collateral cleavage activity of Cas12a, Cas13a, and Cas14 effectors, Clustered Regularly Interspaced Short Palindromic Repeats ...

Additionally, Xu et al. (2024) introduced a triple loop-mediated isothermal amplification-lateral flow immunochromatographic dipstick (LAMP-LFD) detection method, which enables the simultaneous ...

WOH brings together the expertise of our three university partners and four major UK institutes with national capability for working on high consequence pathogens, to provide a broad training and ...

Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein (CRISPR/Cas) technologies have evolved rapidly over the past decade with the continuous discovery of new Cas systems ...

This month's cover highlights the article Immune cells adapt to confined environments in vivo to optimise nuclear plasticity for migration by Helen Weavers and Tua Karling. The cover features confocal ...

Genetic Resource Program, International Maize and Wheat Improvement Center (CIMMYT), El Batan, Mexico Expanding on the precision of CRISPR systems, base editing enables single-base transition ...

The root of their malaise was a genetic experiment. When the monkeys were single-celled embryos, scientists had used CRISPR editing tools to silence, or “knock out”, a gene that helps regulate ...

Building a gene editor took months. With CRISPR even high-schoolers can get hold of editing systems in the time it takes to order RNA sequences online and have them shipped by FedEx. In a short ...

然而，目前还没有能够以通用的方式实现对未经修饰的内源性 RNA 进行单分子活细胞成像。 2025年2月18日，诺贝尔化学奖得主、CRISPR 基因编辑技术先驱 Jennifer Doudna 教授团队在 Nature Biotechnology 期刊发表了题为：Single-molecule live-cell RNA imaging with CRISPR–Csm 的研究论文。