Rather than being famous only in the gene editing field, by revealing the collateral cleavage activity of Cas12a, Cas13a, and Cas14 effectors, Clustered Regularly Interspaced Short Palindromic Repeats ...

In this study, we developed a novel diagnostic tool targeting the speB gene of GAS, designated GAS-MCDA-CRISPR, for the simple, rapid, and sensitive diagnosis of GAS infections. The detection platform ...

Additionally, Xu et al. (2024) introduced a triple loop-mediated isothermal amplification-lateral flow immunochromatographic dipstick (LAMP-LFD) detection method, which enables the simultaneous ...

WOH brings together the expertise of our three university partners and four major UK institutes with national capability for working on high consequence pathogens, to provide a broad training and ...

Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein (CRISPR/Cas) technologies have evolved rapidly over the past decade with the continuous discovery of new Cas systems ...

This month's cover highlights the article Immune cells adapt to confined environments in vivo to optimise nuclear plasticity for migration by Helen Weavers and Tua Karling. The cover features confocal ...

Genetic Resource Program, International Maize and Wheat Improvement Center (CIMMYT), El Batan, Mexico Expanding on the precision of CRISPR systems, base editing enables single-base transition ...

CRISPR最初是作为细菌免疫系统的一部分在细菌中进化而来的，它类似于一套分子剪刀，可以在精确的位置切割DNA，允许它在一条RNA链的帮助下切除基因的问题部分，并将其引导到合适的位置。2023年12月，美国监管机构批准了首个基于crispr的治疗方法，用于治疗镰 ...

Building a gene editor took months. With CRISPR even high-schoolers can get hold of editing systems in the time it takes to order RNA sequences online and have them shipped by FedEx. In a short ...

The root of their malaise was a genetic experiment. When the monkeys were single-celled embryos, scientists had used CRISPR editing tools to silence, or “knock out”, a gene that helps regulate ...