In this review, we summarize TAM ontogeny and polarization, and then explore how TAMs enhance tumor cell migration through the TME, thus facilitating metastasis. We also discuss how chemotherapy and ...

Scientists from the German Cancer Research Center (DKFZ) and ShanghaiTech University have developed an innovative method for ...

Every cell in the body normally has its fixed place as part of a tissue structure. Except for a few cell types, such as blood ...

Successful detection of brain metastases using RAD 101 (18F-Pivalate) in a novel multiparametric imaging methodology ...

Brain metastases are one of the most severe complications of melanoma, the most aggressive type of skin cancer. Researchers ...

Metastatic progression is the deadliest feature of cancer. Cancer cell growth, invasion, intravasation, circulation, arrest/adhesion and extravasation require specific mechanical properties to allow ...

the above findings suggest that tumor stroma is far from a passive bystander during tumor metastases. Tumor cells influence stromal changes including remodeling of the ECM, and this changed stroma ...

The Under-oil Open Microfluidic System enhances tumor cell-ECM interaction studies, improving anti-metastatic drug testing for triple-negative breast cancer.

Three of the four patients with complete remission successfully rejected all metastases within the first 12 weeks with a total of two injections, and remained free of any detectable tumor lesions ...

Lung metastasis (from metastatic breast cancer) resolved - after only 2 months (4 doses) of treatment with Bria-OTS™ ...

Metastasis Formation by Disseminated Tumor Cells A latent phase exists after seeding but prior to bone tumor formation. Proliferative dormancy is a state in which cells are metabolically active ...

Here, we report that TRAIL is constitutively expressed on murine natural killer (NK) cells in the liver and plays a substantial role in suppressing tumor metastasis. Freshly isolated NK cells ...