Caspase-8/caspase-3/GSDME-mediated pyroptosis siRNA敲低GSDME使焦亡细胞减少70%（P<0.001），LDH释放下降50%。 caspase-3抑制剂Z-DEVD-FMK和泛caspase抑制剂Z-VAD-FMK均能阻断GSDME剪切。

S-腺苷甲硫氨酸（SAM）作为甲硫氨酸代谢的关键产物，具有抗炎特性，其水平下降与肝病、神经退行性疾病等多种疾病相关。然而，SAM如何独立于mTORC1通路调控细胞死亡仍不清楚。另一方面，RIPK1作为细胞死亡与炎症的核心介质，其激活机制（尤其与营养信 ...

白血病需要通过基因和染色体的检查来确诊和判断预后。染色体和基因决定细胞生长增殖、分化成熟与衰老死亡，也就是说血细胞的异常增多或减少、分化成熟障碍、过度衰老死亡是由染色体、基因掌控的。如果染色体、基因出现异常，必然会影响血细胞的细胞生长增殖、分化成熟与 ...

Watch FOX 8 News on the new FOX 8 CLE+ TV streaming app! How to download by: Darcie Loreno Posted: Jul 2, 2025 / 06:09 AM EDT Updated: Jul 2, 2025 / 11:55 AM EDT CLEVELAND (WJW) — FOX 8 is growing.

If you're excited about the upcoming Snapdragon 8 Elite phones, you're in for a treat. There are some seriously powerful devices on the way. The iQOO 13 and OnePlus 13 are just around the corner ...

Ocean's 8 isn't quite as smooth as its predecessors, but still has enough cast chemistry and flair to lift the price of a ticket from filmgoers up for an undemanding caper. Read Critics Reviews ...

【导读】结直肠癌（CRC）的治疗仍面临挑战，原因是存在化疗耐药性。7月1日，苏州大学研究团队在期刊《Cell Death Discovery》上发表了研究论文，题为“N6-methyladenosine modification of MEF2A ...

The Fire HD 8 relies on a six-core, 2.0GHz ARM processor, though Amazon doesn’t specify the manufacturer or model. The tablet is available with 3GB of memory and 32GB of storage ($99.99) or 4GB ...

Fans had to wait a long time for Rick and Morty season 8, but now it's finally airing new episodes weekly, both in the US and the UK. Season 8 sees the titular duo and the rest of the Smith family ...

Watch live news from San Diego on CBS 8. Stay up to date on what's happening in your community with a 24/7 live stream and on demand content from CBS 8 Available On Roku Players Amazon Fire TV ...