Fimepinostat（CUDC-907，AbMole，M2111）是一种双靶点小分子抑制剂，同时具备对组蛋白去乙酰化酶（HDACs）和磷脂酰肌醇3激酶（PI3K）的双重抑制活性。CUDC-907独特的分子设计使其在肿瘤相关的基础研究中展现出重要价 ...

Mitochondria, the “powerhouses of the cell,” are vital cellular organelles that govern energy metabolism, maintain redox ...

Researchers at Memorial Sloan Kettering Cancer Center (MSK) have developed some of the first robust laboratory models of a confounding adult-onset inflammatory disease called VEXAS syndrome—shedding ...

Eli Lilly has pulled out of the central nervous system (CNS)-focused portion of a $960 million biobucks deal centered on Rigel Pharmaceuticals’ receptor-interacting serine/threonine-protein kinase 1 ...

Camptothecin （喜树碱，Campathecin，AbMole，M2199）是一种从喜树（Camptotheca acuminata）中提取的天然喹啉类生物碱，Camptothecin是一种拓扑异构酶I（Topoisomerase ...

11月3日，药捷安康在港交所公告， Neurocrine Biosciences, Inc.（纳斯达克：NBIX）与本公司订立一项付特许权使用费的专利转让及研究合作协议，以开发NLRP3抑制剂 ，用于治疗多种疾病。

Bacteria uses multiple defense mechanisms to survive in the host body. Shigella bacteria, that causes colitis, disable multiple host defense pathways ...

你可能会想起在中学课本上学到的相对论，当物体以近光速运动时，它的长度会缩短，这一现象早已被各种各样的物理实验证实。所以你大概会认为，如果有一个立方体从你面前以近光速经过，而你的视力又恰巧非常好，你应该会看到这个立方体在运动方向上被压扁了。

糖尿病患者发生急性心肌梗死（AMI）后，死亡风险比非糖尿病患者高2-3倍，其中心脏-肾脏并发症是糖尿病相关死亡的主要原因。虽然钠-葡萄糖协同转运蛋白2抑制剂（SGLT2i，如恩格列净）已被证实能改善2型糖尿病（T2DM）合并AMI患者的预后并减轻炎症负担，但其背后的具体机制仍不明确。同时，临床实践中SGLT2i的启动时机（立即或延迟数月）也存在疑问。

VEXAS syndrome is an a confounding adult-onset inflammatory disease first described in 2020, which affects 1 in 4,000 men over 50. Now, MSK researchers are shedding new light on its mechanisms and ...

Objective Lupus nephritis (LN) is a prevalent renal manifestation in patients with SLE, with kidney biopsy remaining the gold ...