Fimepinostat（CUDC-907，AbMole，M2111）是一种双靶点小分子抑制剂，同时具备对组蛋白去乙酰化酶（HDACs）和磷脂酰肌醇3激酶（PI3K）的双重抑制活性。CUDC-907独特的分子设计使其在肿瘤相关的基础研究中展现出重要价 ...

Rosiglitazone（BRL ...

糖尿病患者发生急性心肌梗死（AMI）后，死亡风险比非糖尿病患者高2-3倍，其中心脏-肾脏并发症是糖尿病相关死亡的主要原因。虽然钠-葡萄糖协同转运蛋白2抑制剂（SGLT2i，如恩格列净）已被证实能改善2型糖尿病（T2DM）合并AMI患者的预后并减轻炎症负担，但其背后的具体机制仍不明确。同时，临床实践中SGLT2i的启动时机（立即或延迟数月）也存在疑问。

Vorinostat (SAHA, MK0683，AbMole，M1780) ...

近年来传统中药凭借其独特的抗纤维化活性和临床实践价值受到广泛关注[8]。最新研究发现，中药活性成分和复方能够通过特定的方式调节细胞死亡途径，从而改善肾纤维化，为减缓CKD的进展提供了新的研究方向。尽管相关研究数量显著增加，但目前仍缺乏系统性的总结与分 ...

Adequate management of COPD is important because hospitalisation for an acute exacerbation of COPD (AECOPD) is associated ...

在当今塑料污染日益严重的背景下，微塑料 (MPs)和双酚A ...

Data support NEK7 as a potential novel and differentiated therapeutic approach to modulate the NLRP3 inflammasome in multiple cardiovascular and cardiometabolic diseases, including pericarditis and ...

Data support NEK7 as a potential novel and differentiated therapeutic approach to modulate the NLRP3 inflammasome in multiple cardiovascular and ...

Second agreement signed with Novartis to develop novel degraders for immune-mediated diseases, providing upfront payment of $120 million plus ...

Bacteria uses multiple defense mechanisms to survive in the host body. Shigella bacteria, that causes colitis, disable multiple host defense pathways ...