高氧暴露显著提升BPD小鼠肺组织中Caspase-8表达和酶活性，其水平与肺损伤程度正相关。 抑制Caspase-8减轻NLRP3炎症小体激活 Casp8i处理使NLRP3、ASC（凋亡相关斑点样蛋白）表达降低，同时抑制焦亡执行蛋白GSDMD的剪切活化，效果优于单独使用caspase-1抑制剂。

本研究针对抗有丝分裂药物诱导的卵巢癌细胞命运不明确问题，揭示了cGAS/TBK1介导的IRF3磷酸化通过招募RIPK1/FADD/caspase-8复合体 ...

Kashkar团队在细胞培养物和小鼠中研究了caspase-8的生物学作用。他们发现caspase-8的酶活性是抑制细胞焦亡所必需的。Kashkar解释说，“我们发现酶活性 ...

Caspase-8 is frequently deficient in several kinds of human tumors, suggesting that certain effects of this enzyme restrict tumor development. To examine the nature of the cellular function whose ...

AnaSpec has introduced its SensoLyte™ Homogeneous AFC Caspase-8 Assay Kit. The SensoLyte™ Homogeneous AFC Caspase-8 Assay Kit uses Ac-IETD-AFC as the fluorogenic indicator to measure caspase-8 ...

Caspase-8 mutations cause autoimmunity. Studies of human immunodeficiency patients link caspase-8 to homeostatic regulation of the immune system. Jonathan Weitzman. Jonathan Weitzman. This person does ...

The study 'Caspase-8 is the molecular switch for apoptosis, necroptosis and pyroptosis' was published in Nature. The research team studied the biological roles of caspase-8 in cell cultures and mice.

DUBLIN--(BUSINESS WIRE)--The "Caspase 8 - Pipeline Review, H2 2018" drug pipelines has been added to ResearchAndMarkets.com's offering.Caspase 8 (Apoptotic Cysteine Protease or Apoptotic Protease ...

The caspase-8 gene plays a critical role in suppressing metastasis (spread) of neuroblastoma, and the expression of this gene is frequently absent in cancer cells that are aggressively ...

The caspase-8 gene plays a critical role in suppressing metastasis (spread) of neuroblastoma, and the expression of this gene is frequently absent in cancer cells that are aggressively ...