The authors examine the effect of cell-free chromatin particles (cfChPs) derived from human serum or from dying human cells on mouse cells in culture and propose that these cfChPs can serve as ...

But there's a problem: most of the DNA sequences that p53 targets are buried inside nucleosomes, making them difficult to reach. Scientists have long wondered how p53 can reach those "hidden" ...

The eukaryotic genome is organized in the form of a highly compact nucleoprotein complex, the chromatin. Nucleosome, the basic unit of chromatin, consists of ~147 bp of DNA wrapped 1.65 times around a ...

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The Switch/Sucrose Non-Fermentable (SWI/SNF) chromatin remodeling complex comprises 10-15 subunits, which modulate the arrangement, location, or conformation of nucleosomes to upregulate chromatin ...

EDINBURGH, Scotland, Feb. 20, 2025 /PRNewswire/ -- Chromatin Bioscience, a leading innovator in the design of synthetic promoters and gene control systems for cell and gene therapies, is excited to ...

EDINBURGH, Scotland, Jan. 15, 2025 /PRNewswire/ -- Chromatin Bioscience is pleased to announce its ongoing collaboration with EsoBiotec, which has successfully advanced its ESO-T01 in vivo CAR-T ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. The molecular mechanisms controlling the ...