Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Mitotic chromosomes give genome portions the ...

Abstract: Chromosome enumeration is an essential but tedious procedure in karyotyping analysis. To automate the enumeration process, we develop a chromosome enumeration framework, DeepACEv2, based on ...

Translocations are chromosomal “cut and paste” errors that drive many lymphomas, a type of blood cancer and the sixth most common form of cancer overall. This includes mantle cell lymphoma, a rare but ...

Flip open a high-school biology textbook, and the rule seems tidy: two X chromosomes mean girl, and an X paired with a Y means boy. That much smaller Y chromosome carries the SRY gene, which is the ...

Down syndrome is caused by an extra copy of chromosome 21, which leads to a range of developmental differences. Researchers have long sought strategies to correct this duplication, because current ...

This valuable paper describes the stiffness of meiotic chromosomes in both oocytes and spermatocytes. The authors identify differences in stiffness between meiosis I and II chromosomes, as well as an ...

ChromTR, a cutting-edge framework for chromosome detection in metaphase cell images, represents a significant advancement in the field of cytogenetics. This framework, which integrates semantic ...

In cell division, chromosomes change folds and assume different shapes during the cell cycle. We combined a maximum entropy approach with polymer physics to model an ensemble of 3D chromosomal ...

Blinatumomab is a bispecific CD19-directed CD3 T-cell engager. The Food and Drug Administration (FDA) has approved Blincyto ® (blinatumomab) for the treatment of adult and pediatric patients 1 month ...