This approval was based on the phase 3 CodeBreaK 300 trial. CURE® recently spoke with the lead study investigator of the trial, Dr. Marwan G. Fakih, a Professor of Medical Oncology at City of Hope in ...

Lumakras was given accelerated approval by the FDA in 2021 as a second-line treatment for KRASG12C-mutated NSCLC on the back of the single-arm CodeBreaK-100 study ... with its design and was ...

CodeBreak-200 will nevertheless likely serve as a confirmatory study for the approval of Lumakras (sotorasib) in this heavily pretreated patient population, which was granted by the FDA in May 2021.

February 10, 2025 • For people with two hands, one is usually dominant. On a molecular level, life takes this to the extreme. All of the DNA in earthly living things twists to the right, whereas ...

This study reports the computational design of miniprotein binders of the pattern recognition receptor TLR3. When oligomerized, the miniprotein binders induce TLR3 signaling in cells, suggesting ...

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Clinical trial design is a key aspect of the successful conduct of clinical trials. It involves deciding parameters such as the number of patients, the length of the trial, the comparator arm (in ...

Research using the University College London (UCL) COVID-19 Social Study found people also widely feel happier in the summertime than they do during the winter months. Using survey data from ...