DNA hydrogels are biocompatible drug delivery systems for targeted therapeutic interventions. Conventional DNA hydrogels, formed with many DNA nanostructure units, lead to increased preparation costs ...

Comparison of a single-stranded RNA and a double-stranded DNA with their corresponding nucleobases. (Image: Wikimedia Commons, CC SA 3.0) The most common type of base pairing is the Watson-Crick base ...

Detection of mutations and damaged DNA bases is important for the early diagnosis of genetic disease. Here we describe an electrocatalytic method for the detection of single-base mismatches as ...

Partial selectivity in DNA sequence detection was reported by the application of an oligonucleotide probe capable of forming a single double-stranded turn, and exhibiting four to six base ...

In 1950, biochemist Erwin Chargaff found that the arrangement of nitrogen bases in DNA varied widely, but the amount of certain bases always occurred in a one-to-one ratio. These discoveries were ...

Hydrogels are polymeric materials with three-dimensional network structures containing large amounts of water. They serve as ...

By treating DNA as a language, Brian Hie’s “ChatGPT for genomes” could pick up patterns that humans can’t see, accelerating ...

Erwin Chargaff's groundbreaking research, which showed that DNA base pairs had a complementary relationship, laid the foundation for James Watson's and Francis Crick's DNA model. When word spread that ...

A DNA sequence is a specific lineup of chemical base pairs along its strand. The part of DNA that determines what protein to produce and when, is called a gene. First established in 1985 by Sir ...

After sequencing, the duet proprietary software aligns and compares sequence information from the original and copy strands, computing resolved bases that have both genetic and epigenetic information.

Red arrows indicate the nuclear spin axes at the positions of the N3 nitrogen atoms on the guanine (G) bases. Due to the helical structure of DNA, there is an angular deviation in the orientation ...

Innovative Takumi-shaped DNA hydrogels exhibit prolonged retention and drug release, showcasing their potential as biocompatible delivery systems in medicine.