A closeup look at colibactin’s structure reveals chemical motifs that guide its mutation-wreaking “warheads” to specific stretches of DNA.

Colibactin is a powerful toxin produced by Escherichia coli and other bacteria living in the human gut. This highly unstable ...

Small changes in the structure of DNA have been implicated in breast cancer and other diseases, but they've been extremely difficult to detect -- until now. Using what they describe as a 'chemical ...

In the middle of the 20th century, accumulating data suggested that DNA carries life’s genetic information. Biochemists around the world raced to determine its structure. The competition led to some ...

CRISPR-based genome editing has considerable therapeutic potential in a wide range of diseases 1,2,3,4,5. A key challenge is achieving efficient, clinically suitable delivery of genome editing ...

In 1963, Popular Science reported on the Nobel Prize-winning discovery, and the woman who was left out of the accolades. By Bill Gourgey Published May 31, 2022 7:00 AM EDT Get the Popular Science ...

Professor Dongsheng Liu of Tsinghua University, Professor Ziyang Hao of Capital Medical University, and Researcher Yuanchen ...

Chemical insight into biological function is the holy grail of structural biology. Small molecules are central players as building blocks, effectors and probes of macromolecular structure and function ...

RNA, widely known from the COVID-19 vaccine, is not actually a "therapeutic agent," but a technology that delivers the ...

Cancer cells with a cell nucleus that is easily deformed are more sensitive to drugs that damage DNA. These are the findings ...

When commissioned to design the facade and interior of the Institute of Molecular Genetics for the Czech Academy of Science, the Prague-based firm Studio P-H-A decided to add some bling to biomedicine ...