Accurate transmission of the genetic information requires complete duplication of the chromosomal DNA each cell division cycle. However, the idea that replication forks would form at origins of DNA ...

Therefore, DNA lesions cause regions of DNA to remain single-stranded (uncopied). Scientists use the term "stalled forks" for areas of replication forks where DNA polymerization is halted.

Animation of DNA’s knot-like i-motif structure the team mapped in 50,000 locations in the human genome, concentrated in key functional areas including regions that control gene activity Credit ...